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Orthopedic Protocols
Evidence-based protocols for regenerative medicine applications in orthopedics.
Knee Protocols
Comprehensive protocols for treating knee conditions with regenerative medicine approaches.
PRP for Knee Osteoarthritis
Platelet-Rich Plasma Protocol
Evidence Level: High
Indications
- Mild to moderate knee osteoarthritis (KL Grade 1-3)
- Patients with pain and functional limitations
- Patients who have failed conservative management
Key Protocol Elements
- Leukocyte-poor PRP preparation
- 3 injections at 2-week intervals
- Ultrasound guidance recommended
- Post-injection activity modification for 48 hours
BMAC for Cartilage Defects
Bone Marrow Aspirate Concentrate Protocol
Evidence Level: Moderate
Indications
- Focal cartilage defects (ICRS Grade 3-4)
- Osteochondral lesions
- Early osteoarthritis with focal defects
Key Protocol Elements
- Bone marrow aspiration from iliac crest
- Concentration to achieve 5-10x baseline
- Single injection with precision targeting
- Structured rehabilitation protocol
MIBRAR Technique for Knee OA
Minimally Invasive Biological Regeneration and Repair
Proprietary Protocol
Indications
- Moderate to advanced knee osteoarthritis (KL Grade 2-4)
- Patients with significant pain and functional limitations
- Cases with multiple pathologies (cartilage, meniscus, ligament)
Key Protocol Elements
- Combination of PRP, BMAC, and exosomes
- Precision-guided delivery to multiple tissue targets
- Customized formulation based on patient factors
- Comprehensive pre and post-procedure protocols
Adipose-Derived Stem Cells for Knee OA
Microfragmented Adipose Tissue Protocol
Evidence Level: Moderate
Indications
- Moderate knee osteoarthritis (KL Grade 2-3)
- Patients with significant pain despite conservative care
- Patients seeking alternatives to knee replacement
Key Protocol Elements
- Mini-liposuction procedure (50-100cc)
- Mechanical processing without enzymatic digestion
- Single injection with precision guidance
- Gradual return to activities over 2-4 weeks
Evidence Summary
Current evidence levels for regenerative medicine applications in orthopedics.
| Treatment | Condition | Evidence Level | Key Findings |
|---|---|---|---|
| PRP | Knee Osteoarthritis | High | Multiple RCTs and meta-analyses show significant pain reduction and functional improvement for up to 12 months |
| BMAC | Cartilage Defects | Moderate | Several cohort studies show improved pain and function with evidence of cartilage regeneration on MRI |
| Adipose-Derived Stem Cells | Knee Osteoarthritis | Moderate | Early RCTs show promising results with significant improvements in pain and function for up to 24 months |
| PRP | Tendinopathy | High | Strong evidence for lateral epicondylitis and Achilles tendinopathy with multiple positive RCTs |
| BMAC | Disc Degeneration | Emerging | Early case series show promising results but larger controlled studies are needed |
| MIBRAR Technique | Multiple Conditions | Proprietary | Proprietary combination approach with promising early results in registry data |
Request Custom Protocol
Need a protocol for a specific condition not listed here? Our clinical team can develop a customized protocol based on the latest evidence and best practices.
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